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The 0.25 mg starting dose is backed by data from the STEP and SUSTAIN clinical trial programs
It suppresses the IL-6/STAT3 pathway, thereby preventing the HCC cells from inhibiting the cytotoxic effect mediated by natural killer cells (NKs) ( + T cells and induce immunity to tumor rechallenge in Hepa16 allograft mice ( pos CD3 + T cells treated with exendin-4 secreted less IFN-, exhibited weaker migration ability, and upregulated genes related to apoptosis, immunoregulation, and immune deficiency, such as CASP3 and CASP7
patent expiry in 2020, leading to generics soon thereafter
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